@mendelevium Things to try. 1. I have never seen such a high pressure advance setting (S1.25). Are you sure that's right? Try reducing or even disabling it just to see what difference it makes. 2. Do the blobs coincide with retractions? If so,look at your retraction settings but note that there is an interaction between PA and retraction so do the PA first. Using firmware retraction wil enable you to change settings "on the fly". 3. You haven't specified what filament you are using. Have you printed a temperature tower to ascertain the correct value to use for your machine! If not, do so. 4. If the blobs are seemingly random, try another reel of filament but do (3) first. 5. Try an extrusion multiplier of 0.95 or even 0.90 just to see if that helps.